清华大学生命科学学院教授,博士生导师。教育部“长江学者计划”特聘教授,国家杰出青年科学基金项目资助者。1996年获美国纽约爱因斯坦医学院细胞生物学博士学位。长期从事细胞信号转导方面的研究,先后在Nature、Science、Cell Stem Cell、Nat Cell Biol、Molecular Cell、Nat Commun和PNAS等期刊发表论文120多篇,被引用8000多次。曾获何梁何利科技进步奖、中国青年科技奖、美国李氏基金杰出成就奖、中国高等学校十大科技进展、中国细胞生物学会-CST杰出成就奖等。先后兼任Cell Res、JBC、Biochem J、Cell Discovery、Intel J Biochem Cell Biol、Open Biol、中国科学(生命科学)等期刊编委,中国细胞生物学学会理事长。
●主要研究领域(Research Interests)
主要利用膜生物学、分子生物学、生物化学、细胞生物学和发育生物学等多学科技术手段研究TGF-β和Wnt信号的调控以及它们在胚胎发育、干细胞自我更新和分化、肿瘤形成和组织纤维化中的作用。
His research interests concern how TGF-beta and Wnt signaling are regulated and aims to understand their roles in embryogenesis, stem cell self-renewal and differentiation, tissue fibrosis and tumorigenesis.
●代表性论文(selected publications, * corresponding authors)
1.Zhao B, Qi Z, Li Y, Wang C, Fu W, Chen YG*. Non-muscle-myosin-II mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells via the Rac1-PAK1-Akt axis. Nature Communications, 2015, 6:7166.
3.Zuo W, Huang F, Chiang YJ, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen Y, Deng H, Feng X, Luo S, Gao C, Chen YG*. c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor. Molecular Cell, 2013, 49(3):499.
4.Li, Z, Fei T, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG*. BMP4 signaling acts via dual specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells. Cell Stem Cell, 2012, 10(2):171.
5.Gao C, Cao W, Bao L, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG*. Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nature Cell Biology,2010, 12(8):781.
6.Fei T, Xia K, Li Z, Zhou B, Zhu S, Chen H, Zhang J, Chen Z, Xiao H, Han J*, Chen YG*. Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination. Genome Research, 2010, 20(1):36.
8.Wang Q, Huang Z, Xue H, Jin C, Ju X, Han JD, Chen YG*. MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood, 2008, 111(2):588.
●联系方式
chenyeguang@mail.tsinghua.edu.cn
